It looks like 4 8s and 2 10 inch radiators would work well. If you put 2 10 inch radiators in a 2 cube box, along with the 255 grams of weight that comes preinstalled with the 10 inch earthquake radiators, after the sub displacements, that would make it probably a 1.75 cube box tuned to 25 HZ. If you model a traditional ported box for the 4 subs at 1.75 tuned to 25 HZ, that’s a very similar response curve to what dual 10 PR box will be. It’s louder than sealed, not as loud as ported, but will have better SQ than ported. fitting 4 8s and 2 10s on the same baffle won’t be easy, but it is probably possible.